Jesduvroq (daprodustat) is a prescription drug used to treat anemia from chronic kidney disease (CKD) in certain situations. Jesduvroq comes as an oral tablet.

Jesduvroq is used in adults who’ve been receiving dialysis for at least 4 months to treat anemia from CKD.

To learn more about Jesduvroq’s uses, see the “What is Jesduvroq used for?” section below.

Jesduvroq basics

Jesduvroq contains the active ingredient daprodustat. It belongs to a group of drugs called hypoxia-inducible factor prolyl hydroxylase (HIF PH) inhibitors.

Jesduvroq is a brand-name medication. A generic version of the drug isn’t currently available.

Whether you have health insurance or not, cost may be a factor when you’re considering Jesduvroq. What you’ll pay for this drug may depend on several things, such as your treatment plan and the pharmacy you use.

Cost information and savings coupons: You can visit Optum Perks to get price estimates of what you’d pay for Jesduvroq when using coupons from the site. See the coupon options below. (Note: Optum Perks coupons cannot be used with any insurance copays or benefits.)

You can also check out this article to learn more about saving money on prescriptions.

Save on your Jesduvroq prescription

Save on Jesduvroq without insurance.

Enter your information:




1mg jesduvroq (42 Tablets)

Save money without using insurance

Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.

Find your pharmacy

Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.



Was this helpful?

Like most drugs, Jesduvroq may cause mild to serious side effects. The lists below contain some of the more common side effects this drug may cause but don’t include all possible side effects.

Keep in mind that side effects of a drug can depend on:

  • your age
  • other health conditions you have
  • other medications you take

Your doctor or pharmacist can tell you more about the potential side effects of Jesduvroq. They can also suggest ways to help manage them.

Mild side effects

Below is a list of some of the mild side effects Jesduvroq can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read the drug’s prescribing information.

Mild side effects of Jesduvroq that have been reported include:

Mild side effects of many drugs may go away within a few days to a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist.

* To learn more about this side effect, see the “Allergic reaction” section below.

Serious side effects

Serious side effects from Jesduvroq can occur, but they aren’t common. If you have serious side effects from Jesduvroq, call your doctor right away. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Serious side effects of Jesduvroq that have been reported include:

* For more information, see the “What should be considered before taking Jesduvroq?” section.
† To learn more about this side effect, see the “Allergic reaction” section just below.

Allergic reaction

Some people may have an allergic reaction to Jesduvroq.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can make it difficult to breathe.

Call your doctor right away if you have an allergic reaction to Jesduvroq. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Your doctor will recommend the dosage of Jesduvroq that’s right for you. Below are commonly used dosages, but always take the dosage your doctor prescribes for you.

Form and strengths

Jesduvroq comes as an oral tablet. It’s available in five strengths:

  • 1 milligram (mg)
  • 2 mg
  • 4 mg
  • 6 mg
  • 8 mg

Recommended dosages

The typical Jesduvroq dosage for adults who’ve been receiving dialysis for at least 4 months to treat anemia from CKD depends on the following:

  • your hemoglobin level, measured in grams per deciliter (g/dL)
  • whether you’re currently taking an erythropoietin-stimulating agent (ESA). ESAs are also usually prescribed to increase your red blood cell count.
  • your liver function

If you’re not taking an ESA, your doctor will use your hemoglobin level to prescribe your initial Jesduvroq dosage:

Hemoglobin level (before starting Jesduvroq)Usual dosage
less than 9 g/dL4 mg once daily
9–10 g/dL 2 mg once daily
over 10 g/dL1 mg once daily

If you are taking an ESA, your doctor will use your ESA dosage to prescribe your initial Jesduvroq dosage. Typically, this dosage may be 4 mg, 6 mg, 8 mg, or 12 mg once per day.

Examples of ESAs include:

  • epoetin alfa (Epogen, Procrit)
  • darbepoetin alfa (Aranesp)
  • methoxy PEG-epoetin beta (Mircera)

You won’t take both Jesduvroq and an ESA. Your doctor will explain how to stop taking your ESA when you start Jesduvroq.

Whether you’re switching to Jesduvroq from an ESA or not, the maximum dosage of Jesduvroq is 24 mg once daily.

If you have moderate liver problems, your doctor will likely prescribe a lower starting dose of Jesduvroq. But if you have severe liver problems, they’ll likely prescribe a different treatment.

Your doctor will order blood tests to check your iron levels and liver function before you start Jesduvroq. Your hemoglobin levels will also be checked routinely during your treatment. Your doctor may adjust your dose based on your hemoglobin level. Or they may pause your Jesduvroq treatment until your hemoglobin levels are within an acceptable range for you.

If you take Jesduvroq for 6 months and your hemoglobin levels aren’t improving, your doctor will likely recommend a different treatment option.

To learn more about Jesduvroq’s dosage, see this article.

Questions about taking Jesduvroq

Below are some common questions about taking Jesduvroq.

  • Can Jesduvroq be chewed, crushed, or split? No, you should not chew, crush, or split Jesduvroq tablets. You should swallow them whole. If you have trouble swallowing pills, check out this article or ask your doctor or pharmacist for advice.
  • Should I take Jesduvroq with food? Jesduvroq can be taken with or without food.
  • Is there a best time of day to take Jesduvroq? Jesduvroq can be taken at any time of day, regardless of when you receive dialysis. But it’s best to take it around the same time each day. This helps keep a consistent level of the drug in your body, which helps Jesduvroq work effectively.
  • What if I miss a dose of Jesduvroq? If you miss a dose of Jesduvroq, take it as soon as you remember. But if it’s the same day as your next dose, skip the missed dose and take the next dose at its usual time. You should not take two doses at once to make up for a missed dose. Doing so could increase your risk of side effects.
  • Will I need to take Jesduvroq long term? Jesduvroq is typically used as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term. But if this drug hasn’t treated your anemia after 6 months, your doctor will likely have you stop Jesduvroq and prescribe a different medication.


Do not take more Jesduvroq than your doctor prescribes, as this can lead to harmful effects.

Symptoms of overdose

Symptoms caused by an overdose can include headache and nausea.

What to do in case you take too much Jesduvroq

Call your doctor if you think you’ve taken too much Jesduvroq. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 or your local emergency number. Or go to the nearest emergency room.

Jesduvroq is used to treat anemia from CKD in adults who’ve received dialysis for at least 4 months. Anemia may cause symptoms such as tiredness, cold hands and feet, and dizziness when standing.

Your kidneys make a hormone called erythropoietin. Erythropoietin helps make red blood cells. But with CKD, your kidneys don’t function as they should. This means your kidneys may make less erythropoietin. Less erythropoietin may cause you to have lower amounts of red blood cells than normal, leading to anemia.

Jesduvroq works to treat anemia from CKD by increasing the level of erythropoietin in your body. This leads to more red blood cells.

You should not take Jesduvroq for anemia from CKD if you’re not receiving dialysis. And it’s not meant to improve overall well-being or tiredness that often comes with the condition. Jesduvroq is also not meant to take the place of red blood cell transfusions if your anemia needs rapid treatment.

Below is important information you should consider before taking Jesduvroq.


Taking a drug with certain medications, vaccines, foods, and other things can affect how the drug works. These effects are called interactions. Jesduvroq can interact with several other medications.

Before starting Jesduvroq treatment, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.

Drug interactions

Below is a list of medications that can interact with Jesduvroq. This list does not contain all drugs that may interact with Jesduvroq. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Type of drugDrug examples
certain drugs that slow down the CYP2C8 enzyme* gemfibrozil (Lopid)
clopidogrel (Plavix)
certain drugs that speed up the CYP2C8 enzyme*rifampin (Rimactane, Rifadin)

*Cytochrome P450 2C8 (CYP2C8) is an enzyme in the liver that helps to break down certain drugs, including Jesduvroq.

Jesduvroq and alcohol

Alcohol isn’t known to interact with Jesduvroq, but it may worsen certain symptoms of anemia, such as dizziness. Drinking alcohol while taking this drug may also increase the risk of damage in your gastrointestinal (GI) tract. Because of this, your doctor may recommend that you limit the amount of alcohol you drink during Jesduvroq treatment.

Pregnancy and breastfeeding

You should not use Jesduvroq during pregnancy.

You should also not breastfeed while taking Jesduvroq and for 1 week after your final dose.

Boxed warning

Jesduvroq has a boxed warning about the risk of death and serious cardiovascular (heart and blood vessel) problems. A boxed warning is the most serious warning from the FDA. It alerts doctors and patients about drug effects that may be dangerous.

Taking Jesduvroq increases your risk of serious cardiovascular problems, such as stroke and heart attack. It also increases your risk of developing blood clots in your veins where your dialysis machine is inserted.

If you’re having a stroke, you may have difficulty speaking or walking. If you’re having a heart attack, you may experience chest pain or shortness of breath. If you have a blood clot, the affected area of your body may be discolored or more tender than usual. If you think you’re experiencing one of these conditions, seek medical help immediately.

Because of these risks, doctors will not prescribe Jesduvroq for you if you’ve had a heart attack, stroke, or certain other conditions that restrict blood flow to your heart in the past 3 months.

Red blood cells contain hemoglobin. Jesduvroq increases hemoglobin levels to treat anemia. But increasing hemoglobin levels too quickly (higher than 1 g/dL over 2 weeks) increases the risk of these cardiovascular problems. Having a hemoglobin level over 11 g/dL also increases your risk.

Because of these risks, your doctor will prescribe the lowest Jesduvroq dosage that’s effective for you. And they’ll monitor your hemoglobin levels throughout your treatment with this drug. If your levels are higher than recommended for you, your doctor may lower your dose or pause your treatment until your levels are acceptable.

Talk with your doctor to learn more about the risks of taking Jesduvroq.


Jesduvroq can sometimes cause harmful effects in people with certain conditions. This is known as a drug-condition interaction. Other factors may also affect whether Jesduvroq is a good treatment option for you.

Talk with your doctor about your health history before starting this medication. Be sure to tell them if any of the following factors apply to you:

*Cytochrome P450 2C8 (CYP2C8) is an enzyme in the liver that helps to break down certain drugs, including Jesduvroq.

Find answers to some commonly asked questions about Jesduvroq.

Will Jesduvroq cure my anemia caused by chronic kidney disease (CKD)?

No, Jesduvroq does not cure anemia from CKD. There’s currently no cure for this condition. But Jesduvroq works to manage the symptoms of anemia.

If you have other questions about what to expect from Jesduvroq treatment, talk with your doctor.

How does Jesduvroq compare with Procrit?

Both Jesduvroq and epoetin alfa (Procrit) are used to treat anemia from CKD.

In addition, Procrit is used to treat anemia in certain people, including those who:

  • have HIV
  • are taking certain types of chemotherapy drugs
  • are trying to reduce the need for red blood cell transfusions before certain planned surgeries

(Jesduvroq is not used for these conditions.)

Another difference is that Jesduvroq is approved for anemia from CKD in adults only. Procrit, on the other hand, can also be used in children as young as 1 month old, depending on the cause of anemia.

Jesduvroq comes as an oral tablet. Procrit is either given as an injection under your skin or an intravenous (IV) infusion (an injection into a vein over a period of time).

Jesduvroq and Procrit belong to different groups of drugs.

If you have other questions about how these medications compare, talk with your doctor. They can help you find the treatment that’s best for you.

Is Jesduvroq used for other types of anemia?

Jesduvroq is not approved to treat other types of anemia. But your doctor may prescribe it off-label for this use. (Off-label use is when a drug is prescribed to treat a condition other than those it’s approved for.)

Jesduvroq is approved to treat anemia from CKD in adults who’ve received dialysis for at least 4 months. But some studies have shown that Jesduvroq may be as effective as other anemia treatments, such as darbepoetin alfa, in people who aren’t receiving dialysis.

To learn more about treatment options for other types of anemia, including Jesduvroq, talk with your doctor.

Jesduvroq is the first oral option available to treat anemia from CKD in adults who’ve received dialysis for at least 4 months. But there are other drugs given as an injection under the skin or intravenous (IV) infusion (injection into a vein over a period of time) available for this condition. These include:

  • epoetin alfa (Epogen, Procrit)
  • darbepoetin alfa (Aranesp)
  • methoxy PEG-epoetin beta (Mircera)

If you’d like to consider an alternative to Jesduvroq, talk with your doctor. They can tell you about other treatments that might work well for you.

If you have questions about Jesduvroq, talk with your doctor or pharmacist. Questions you may want to ask include:

  • Do any of the other medications I take interact with Jesduvroq?
  • What options do I have to treat my anemia if I’ve had a heart attack in the past 3 months?
  • Do older adults need a lower dose of Jesduvroq?

To learn more about Jesduvroq, see these articles:

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy, where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.