Vosevi (sofosbuvir/velpatasvir/voxilaprevir) is a prescription oral tablet used to treat chronic (long lasting) hepatitis C in certain adults. It’s usually taken once per day. Vosevi belongs to a group of drugs called direct-acting antivirals.

This section describes the usual dosage of Vosevi. Keep reading to learn more.

What is Vosevi’s form?

Vosevi comes as an oral tablet.

What strength does Vosevi come in?

Vosevi has three active ingredients in one tablet. (An active ingredient is what makes a drug work.)

Each Vosevi tablet contains:

  • 400 milligrams (mg) of sofosbuvir
  • 100 mg of velpatasvir
  • 100 mg of voxilaprevir

What are the usual dosages of Vosevi?

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosage for chronic hepatitis C

The typical Vosevi dosage for adults with chronic hepatitis C is one tablet taken once per day for 12 weeks.

Your doctor will order blood tests and monitor you while you’re taking Vosevi to see how your body responds to treatment. If you have questions about your dosage, talk with your doctor or pharmacist to learn more.

Is Vosevi used long term?

No, Vosevi isn’t used as a long-term treatment. Typically, the drug is taken for 12 weeks to treat chronic hepatitis C.

If you have questions about how long you’ll take Vosevi, talk with your doctor.

Vosevi comes as an oral tablet. You’ll take one tablet per day with food. Try to take Vosevi around the same time each day. This is to keep consistent levels of the medication in your body, which helps it effectively treat your condition.

It’s not known whether it’s safe to crush, cut, or chew Vosevi, so it’s best to swallow the tablet whole. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication.

If you need to take an antacid that contains aluminum or magnesium, you should take it at least 4 hours before or 4 hours after Vosevi.

For information on the expiration, storage, and disposal of Vosevi, talk with your doctor or pharmacist.

Accessible drug containers and labels

Some pharmacies provide medication labels that:

  • have large print
  • use braille
  • feature a code you can scan with a smartphone to change the text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.

Let your pharmacist know if you have trouble opening medication bottles. They may have tips to help, or they may be able to supply Vosevi in an easy-open container.

If you miss a dose of Vosevi, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at its usual time. You should not take take two doses of Vosevi at once to make up for a missed dose. Doing so can increase your risk of side effects.

If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.

It’s important to take Vosevi every day. Missing doses can make the drug less effective in curing your hepatitis C. If you need help remembering to take your dose of Vosevi on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Vosevi than your doctor prescribes, as this can lead to harmful effects.

What to do in case you take too much Vosevi

Call your doctor right away if you think you’ve taken too much Vosevi. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Below are answers to some commonly asked questions about Vosevi’s dosage.

Is Vosevi’s dosage similar to the dosages of Epclusa?

The forms and how often you take each drug are similar, but there are some differences as well. Vosevi and sofosbuvir/velpatasvir (Epclusa) are both approved to treat chronic hepatitis C in adults. Epclusa is also approved for use in some children.

Both drugs come as oral tablets that are taken once per day. Epclusa also comes as oral pellets. The drugs come in different strengths.

Epclusa and Epclusa contain two of the same active ingredients, sofosbuvir and velpatasvir. But Vosevi also contains voxilaprevir.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Vosevi to start working?

Vosevi starts to work after your first dose. But it may take up to 12 weeks for your condition to improve. Vosevi is an antiviral medication that works by stopping the hepatitis C virus from copying itself and spreading to damage your liver cells. Once the virus stops growing and spreading, it eventually dies.

Your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

If you have other questions about what to expect from your Vosevi treatment, talk with your doctor.

The sections above describe the usual dosage provided by Vosevi’s manufacturer. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you.

Remember, you should not change your dosage of Vosevi without your doctor’s recommendation. Only take Vosevi exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Here are some examples of questions you may want to ask your doctor:

  • If I’m having side effects from Vosevi, could my dosage be lowered?
  • Will I need to take Vosevi for longer than 12 weeks?
  • Would I have to restart my Vosevi treatment if I stop taking it before reaching 12 weeks?

To learn more about Vosevi, see this article.

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.