Takhzyro (lanadelumab-flyo) is a prescription drug that may help prevent hereditary angioedema (HAE). The drug comes as liquid solution for injection under your skin. It’s usually given once every 2 weeks.

Takhzyro is prescribed to adults and certain children to prevent HAE attacks. HAE is a rare genetic condition that causes sudden swelling of your face, hands, genitals, and feet. It can also cause swelling of other body areas, including your gastrointestinal tract and airways. The condition may be severe or even life threatening.

The active ingredient in Takhzyro is lanadelumab-flyo. Takhzyro is a biologic drug made from living cells. It belongs to a group of drugs called plasma kallikrein inhibitors, which are monoclonal antibodies.

This article describes the dosages of Takhzyro, as well as its strengths and how it’s given. To learn more about Takhzyro, see this in-depth article.

This section describes the usual dosages of Takhzyro. Keep reading to learn more.

What’s Takhzyro’s form?

Takhzyro is available as a liquid solution in a single-dose prefilled vial or syringe. It can be given as an injection under your skin by a healthcare professional or caregiver or as a self-injection.

What strengths does Takhzyro come in?

Takhzyro comes as:

  • 150 milligrams (mg) per 1 milliliter (mL) of solution in a single-dose prefilled syringe
  • 300 mg per 2 mL of solution in a single-dose prefilled syringe
  • 300 mg per 2 mL of solution in a single-dose vial

What are the usual dosages of Takhzyro?

The information below describes dosages that are commonly prescribed or recommended. If you give yourself doses of Takhzryo, be sure to give the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage for preventing HAE attacks

The typical Takhzyro dosage for adults to prevent HAE attacks is 300 mg given as an injection under their skin every 2 weeks.

Your doctor may adjust your dosage to 300 mg every 4 weeks if you haven‘t had an attack in more than 6 months.

Do not change your dosage of Takhzyro on your own.

Talk with your doctor or pharmacist if you have questions about your dosage of Takhzyro.

What’s the dosage of Takhzyro for children?

Takhzyro is prescribed to help prevent HAE attacks in children ages 2 years and older. Your child’s dosage is based on their age and the severity of their condition.

Dosage for children 2 years old to less than 6 years old

Takhzyro’s dosage for children 2 years old to under 6 years old is 150 mg given as an injection under their skin once every 4 weeks. It may be given by a healthcare professional or a caregiver.

Dosage for children 6 years old to less than 12 years old

Takhzyro’s typical dosage for children 6 years old to under 12 years old is 150 mg given as an injection under their skin once every 2 weeks. Your child’s doctor may adjust their dosage to 150 mg given once every 4 weeks if your child hasn’t had an HAE attack in more than 6 months.

Dosage for children 12 years and older

The dosage for children 12 years and older is the same as the dosage for adults. To learn more, see the “What are the usual dosages of Takhzyro?” section above.

For more information about Takhzyro’s dosage for children, talk with your child’s doctor or a pharmacist.

How to give Takhzyro

Takhzyro comes as a liquid solution in single-dose prefilled syringes or vials for injection under your skin. A healthcare professional may give you doses of Takhzryo, or they may show you or a caregiver how to give doses at home.

If giving Takhzyro yourself:

  • Take the medication out of the refrigerator 15 minutes before you need to give a dose of Takhzyro.
  • Do not shake Takhzyro prefilled syringes too hard.
  • Inject Takhzyro under the skin of your thigh, upper arm, or abdomen.

Your doctor will explain how Takhzyro is given. You can also see step-by-step instructions on how to give Takhzryo.

Talk with your doctor or pharmacist if you have questions about your dosage of Takhzyro and how to give it.

Is Takhzyro prescribed long term?

Yes, Takhzyro is usually prescribed as a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely receive it long term.

Do not inject more Takhzyro than your doctor prescribes, as this can lead to harmful effects.

What to do in case you inject too much Takhzyro

Call your doctor right away if you think you’ve injected too much Takhzyro. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.