Skyrizi (risankizumab-rzaa) is a prescription drug used to treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease. Skyrizi isn’t known to interact with alcohol, medications, or supplements. But you should not receive live vaccines with Skyrizi.

Skyrizi is used in certain adults to treat:

Skyrizi comes as a liquid solution. It can be given as an injection under your skin or by a healthcare professional as an intravenous (IV) infusion. (An IV infusion is an injection into your vein given over a period of time.)

The active ingredient in Skyrizi is risankizumab-rzaa. (The reason “-rzaa” appears at the end of the drug’s name is to show that it’s distinct from similar medications that may be created in the future.)

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Skyrizi’s possible interactions. And for more information about Skyrizi, including details about its uses, see this article.

There are no reports of Skyrizi interacting with specific drugs. But interactions with other medications may be recognized in the future. For example, people who have received Skyrizi since it became available could report suspected interactions.

Before starting Skyrizi, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Skyrizi interacts with herbs or vitamins and supplements, see the “Are there other interactions with Skyrizi?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

Certain health conditions or other factors could increase your risk of harm with Skyrizi. These factors are known as contraindications. In such cases, your doctor may not prescribe this drug for you. The list below includes the contraindications of Skyrizi.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Skyrizi or any of its ingredients, your doctor likely won’t prescribe Skyrizi for you. This is because receiving Skyrizi could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

If you’ve ever had an allergic reaction to this drug, talk with your doctor before starting Skyrizi treatment. They can determine whether it’s safe for you.

Skyrizi is not known to interact with alcohol. But alcohol may worsen symptoms of the conditions Skyrizi is used to treat. So your doctor may recommend that you avoid or limit alcohol consumption during Skyrizi treatment.

If you have questions about consuming alcohol during treatment with this drug, talk with your doctor or pharmacist.

Skyrizi may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Skyrizi.

Does Skyrizi interact with supplements?

Before starting Skyrizi, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Skyrizi and herbs

There are currently no reports of Skyrizi interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products during treatment with Skyrizi.

Skyrizi and vitamins

There are currently no reports of Skyrizi interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products during treatment with Skyrizi.

Does Skyrizi interact with food?

There are currently no reports of Skyrizi interacting with food. If you have questions about eating certain foods during your treatment with Skyrizi, talk with your doctor.

Does Skyrizi interact with vaccines?

You should not receive live vaccines* during treatment with Skyrizi. Doing so increases your risk of infection. Examples of live vaccines include chickenpox, rotavirus, and measles, mumps, rubella (MMR).

If you need a vaccine, talk with your doctor first to make sure it’s safe.

* Live vaccines contain weakened versions of the virus or bacteria that they’re meant to protect against.

Does Skyrizi interact with lab tests?

There are currently no reports of Skyrizi interacting with lab tests. If you have questions about having certain lab tests during treatment with Skyrizi, talk with the healthcare professional ordering the test.

Does Skyrizi interact with cannabis or CBD?

There are currently no reports of Skyrizi interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Skyrizi.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may increase the risk of interactions with Skyrizi. Before starting this medication, talk with your doctor about your health history. They’ll determine whether Skyrizi is right for you.

Health conditions or other factors that might interact with Skyrizi include:

Liver problems: Skyrizi treatment may lead to liver problems for people with Crohn’s disease. This risk may be higher for people who already have a liver problem, such as cirrhosis (liver scarring). Your doctor can determine whether Skyrizi is a safe treatment option for you.

Infection, including tuberculosis (TB): Skyrizi may lead to new or worsened infections, including TB. Before receiving Skyrizi, tell your doctor if you have an infection. They’ll likely treat it before you start Skyrizi treatment.

Your doctor will likely order a TB test before prescribing Skyrizi for you. If the test shows you have TB, your doctor will treat the TB before you start Skyrizi treatment.

Pregnancy: It’s not known whether Skyrizi is safe to receive during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before starting Skyrizi treatment.

If you do use Skyrizi while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Skyrizi. To learn more, talk with your doctor or call 877-302-2161.

Breastfeeding: It’s not known whether it’s safe to receive Skyrizi while breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Skyrizi or any of its ingredients, your doctor will likely not prescribe Skyrizi for you. This is because the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Skyrizi. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • whether you drink alcohol or use cannabis
  • other medications you take, as well as any vitamins, supplements, and herbs
  • what to do if you start taking a new drug during Skyrizi treatment

Your doctor or pharmacist can also help you fill out a medication list.

It’s also important to understand Skyrizi’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Skyrizi, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Using Skyrizi exactly as prescribed can also help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.