Motegrity Interactions: Alcohol, Medications, and Others

Before you start taking Motegrity, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Motegrity interacts with herbs or vitamins and supplements, see the “Are there other interactions with Motegrity?” section below.)

Motegrity can interact with an antibiotic called fosfomycin (Monurol). It can make fosfomycin less effective. For more information about this interaction, see the “Drug interactions explained” section below.

If you have questions about other drug interactions that may affect you, talk with your doctor or pharmacist.

Certain health conditions or other factors could raise your risk of harm if you take Motegrity. In such cases, your doctor may not prescribe Motegrity for you. These are known as contraindications. The list below includes contraindications of Motegrity.

If you have severe inflammatory bowel disease: If you have severe inflammatory bowel disease (IBD), your doctor likely won’t prescribe Motegrity for you. This is because the drug increases the muscle contractions in your intestine, which can be harmful if you have severe IBD. Examples of severe IBD include ulcerative colitis, Crohn’s disease, and toxic megacolon. Your doctor can recommend other treatments that may be better options for you.

If you have a blockage or tear in your intestine: If you have a blockage or perforation (tear) in your intestine, your doctor likely won’t prescribe Motegrity for you. This is because the drug increases the muscle contractions in your intestine, which can be harmful in these situations. Talk with your doctor about other treatments that may be better options for you.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Motegrity or any of its ingredients, your doctor likely won’t prescribe Motegrity for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Before you start taking Motegrity, talk with your doctor if any of the factors above apply to you. Your doctor can determine whether Motegrity is safe for you to take.

Motegrity is not known to interact with alcohol. But Motegrity and alcohol can cause some similar side effects, such as headache, nausea, vomiting, diarrhea, and dizziness. So you may be more likely to experience these side effects if you drink alcohol during your Motegrity treatment.

If you have questions about consuming alcohol while taking Motegrity, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Motegrity.

Interaction with fosfomycin

Motegrity can interact with fosfomycin (Monurol), which is used to treat certain urinary tract infections (UTIs).

What could happen

Taking Motegrity with fosfomycin can make fosfomycin move through your intestine faster than usual. Because of this, your body may not absorb the full dose of fosfomycin. This can make it less effective at treating a UTI.

What you can do

If your doctor prescribes Motegrity with fosfomycin, they’ll likely recommend taking your fosfomycin dose at a different time of day than your Motegrity dose.

If you still have UTI symptoms after taking Motegrity and fosfomycin together, tell your doctor.

If you have questions about taking Motegrity with fosfomycin, talk with your doctor or pharmacist.

Motegrity may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Motegrity.

Does Motegrity interact with supplements?

Before you start taking Motegrity, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Motegrity and herbs

There are currently no reports of Motegrity interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Motegrity.

Motegrity and vitamins

There are currently no reports of Motegrity interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Motegrity.

Does Motegrity interact with food?

There are currently no reports of Motegrity interacting with food. If you have questions about eating certain foods during your treatment with Motegrity, talk with your doctor.

Does Motegrity interact with vaccines?

There are currently no reports of Motegrity interacting with vaccines. If you have questions about getting certain vaccines during your Motegrity treatment, talk with your doctor.

Does Motegrity interact with lab tests?

There are currently no reports of Motegrity interacting with lab tests. If you have questions about having certain lab tests during your treatment with Motegrity, talk with the healthcare professional ordering the test.

Does Motegrity interact with cannabis or CBD?

There are currently no reports of Motegrity interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Motegrity.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Motegrity. Before taking Motegrity, talk with your doctor about your health history. They’ll determine whether Motegrity is right for you.

Health conditions or other factors that might interact with Motegrity include:

Kidney problems: If you have kidney problems, Motegrity could build up in your body and raise your risk of side effects. Because of this, your doctor may prescribe a dosage of Motegrity that’s lower than usual.

Blockage, tear, or severe inflammation in your intestines: If you have a blockage, tear, or severe inflammation in your intestines, your doctor likely won’t prescribe Motegrity. For more details, see the section above called “When should I avoid Motegrity?”

Mental health problems: If you have a history of mental health problems, such as depression or suicidal thoughts, talk with your doctor before taking Motegrity. Motegrity can cause and worsen depression and suicidal thoughts in some people. If you take Motegrity, tell your doctor right away if you have any unusual changes in your mood, feelings, thoughts, or behavior.

Pregnancy: It’s not known whether Motegrity is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Motegrity.

Breastfeeding: It’s not known whether it’s safe to take Motegrity while breastfeeding. The drug passes into breast milk, but it isn’t known whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Motegrity or any of its ingredients, your doctor will likely not prescribe Motegrity. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Taking certain steps can help you avoid interactions with Motegrity. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

• whether you drink alcohol or use cannabis
• other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a medication list)
• what to do if you start taking a new drug during your Motegrity treatment

It’s also important to understand Motegrity’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. The paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Motegrity, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Motegrity exactly as prescribed can also help prevent interactions.

If you still have questions about Motegrity and its possible interactions, talk with your doctor.

Questions you may want to ask your doctor include:

• Can I take indigestion remedies with Motegrity?
• Can I take Motegrity if I have a stomach ulcer?
• Could Motegrity interact with Wegovy?

To learn more about Motegrity, see these articles:

• Motegrity (prucalopride)
• Side Effects of Motegrity: What You Need to Know
• Dosage Details for Motegrity
• Motegrity and cost

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.