Loqtorzi (toripalimab-tpzi) is a prescription drug that treats a certain type of head and neck cancer. A healthcare professional gives you the solution by infusion into a vein. The dosage depends on your treatment plan.

Loqtorzi is used in adults to treat a type of head and neck cancer called nasopharyngeal cancer. Specifically, it’s used:

Definitions of some terms used above are:

  • Locally advanced: The cancer has spread to nearby tissues.
  • Metastatic: The cancer has spread to other areas of the body beyond where it started.
  • Recurrent: The cancer has returned.
  • Unresectable: The cancer cannot be removed by surgery.

The active ingredient in Loqtorzi is toripalimab-tpzi. Loqtorzi belongs to a group of drugs called programmed death receptor-1 blocking antibody. It’s a biologic drug made from living cells.

This article describes the dosages of Loqtorzi, as well as its strength and how it’s given. To learn more about Loqtorzi, see this in-depth article.

This section describes the usual dosages of Loqtorzi. Keep reading to learn more.

What is Loqtorzi’s form?

Loqtorzi is available as a liquid solution for intravenous (IV) infusion. A healthcare professional injects it into your vein over a period of time.

What strength does Loqtorzi come in?

Loqtorzi comes in one strength of 240 milligrams (mg) per 6 milliliters (mL) of solution. Doctors and pharmacists may refer to this as 40 mg/mL.

What are the usual dosages of Loqtorzi?

Your dosage for Loqtorzi depends on your treatment plan.

The information below describes dosages that are commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for nasopharyngeal carcinoma

The typical Loqtorzi dosage for adults with nasopharyngeal cancer depends on how the medication is given.

When given with the chemotherapy drugs cisplatin and gemcitabine: The dosage of Loqtorzi when given with these drugs is 240 mg every 3 weeks. You’ll receive treatment:

  • until your condition worsens, or
  • until you cannot tolerate the medication, or
  • up to 24 months

When given by itself: The dosage of Loqtorzi when given alone is based on your body weight expressed in kilograms (kg). The dosage is 3 mg/kg of body weight every 2 weeks. For reference, 1 kg is about 2.2 pounds (lb). For example, if you weigh 85 kg (about 187 lb), your dosage would be 255 mg every 2 weeks.

You’ll receive treatment until your condition worsens or you cannot tolerate the medication.

How to use Loqtorzi

Loqtorzi comes as a solution for IV infusion. A healthcare professional gives this by injection into your vein over a period of time. You’ll receive infusions at your doctor’s office, at a clinic, or in the hospital.

You’ll receive your first dose over 60 minutes. If you don’t have any infusion side effects after that dose, you may receive your other doses over 30 minutes.

If you have questions about how you’ll receive Loqtorzi, talk with your doctor.

Is Loqtorzi used long term?

Yes, Loqtorzi is usually used as a long-term treatment. You and your doctor can discuss whether it’s safe and effective for your condition. If you determine that it is, you’ll likely receive it long term.

When given with the chemotherapy drugs cisplatin and gemcitabine: You’ll receive Loqtorzi treatment:

  • until your condition worsens, or
  • until you cannot tolerate the medication, or
  • up to 24 months

When given by itself: You’ll receive treatment Loqtorzi until your condition worsens or you cannot tolerate the medication.

If you have questions about how long your treatment with Loqtorzi will last, talk with your doctor.

Below are answers to some commonly asked questions about Loqtorzi’s dosage.

How long does it take for Loqtorzi to start working?

Loqtorzi starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working for your condition.

If you have other questions about what to expect from your Loqtorzi treatment, talk with your doctor.

Can Loqtorzi be used for other types of cancer? If so, what’s the dosage?

No, Loqtorzi is not used for other types of cancer. However, ongoing studies would help us learn whether toripalimab-tpzi (Loqtorzi) may be effective for other cancers. These include non-small cell lung cancer.

Loqtorzi is approved to treat only nasopharyngeal cancer. Because of this, the drugmaker doesn’t provide recommended dosages for other cancers.

Many options are available to treat different types of cancer. If you have questions about treatments for cancers besides nasopharyngeal cancer, talk with your doctor.

What should I do if I miss a dose of Loqtorzi?

If you miss an appointment to receive a dose of Loqtorzi, call your doctor’s office as soon as possible to reschedule. They’ll give you the missed dose and adjust your dosing schedule if needed.

If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.