Januvia (sitagliptin) is a prescription drug that’s used to treat type 2 diabetes. This drug can interact with other medications. For example, Januvia can interact with other diabetes medications and insulin.

Januvia is used in adults to treat type 2 diabetes. It comes as an oral tablet and contains the active drug sitagliptin.

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Keep reading to learn about Januvia’s possible interactions. And for more information about Januvia, including details about its uses, see this article.

Before you start taking Januvia, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Januvia interacts with herbs or vitamins and supplements, see the “Are there other interactions with Januvia?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Januvia. Keep in mind that this table does not include all drugs that may interact with Januvia. For more information about these interactions, see the “Drug interactions explained” section below.

Drug group or drug nameDrug examplesWhat can happen
glinides • nateglinide
• repaglinide
can increase the risk of low blood sugar
sulfonylureas glimepiride (Amaryl)
glipizide
• glipizide extended release (Glucotrol XL)
• others
can increase the risk of low blood sugar
insulin• lispro (Humalog)
• aspart (NovoLog)
glargine (Lantus, others)
can increase the risk of low blood sugar

Certain health conditions or other factors could raise your risk of harm if you take Januvia. In such cases, your doctor may not prescribe Januvia for you. These are known as contraindications.

The following is a Januvia contraindication:

  • If you’ve had an allergic reaction: If you’ve had an allergic reaction to Januvia or any of its ingredients, your doctor likely won’t prescribe Januvia for you. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Januvia is not known to interact with alcohol. But alcohol can have an effect on your blood sugar. And Januvia helps manage blood sugar levels in adults with type 2 diabetes. Because of this, drinking alcohol during Januvia treatment may make it harder to manage your blood sugar.

If you have questions about consuming alcohol while taking Januvia, talk with your doctor or pharmacist.

Learn more about certain drug interactions that can occur with Januvia.

Interaction with glinides

Januvia can interact with glinides, which are used to treat type 2 diabetes.

Examples of glinide medications include:

  • nateglinide
  • repaglinide

What could happen

Taking Januvia with glinides can raise your risk of low blood sugar. Signs and symptoms of low blood sugar include:

  • confusion
  • dizziness
  • drowsiness
  • headache
  • hunger
  • irritability
  • nervousness
  • weakness

What you can do

If you take Januvia with a glinide drug, your doctor may prescribe a dosage of the glinide drug that’s lower than usual. You should not take a dose of either medication that’s higher than your doctor prescribes.

Your doctor can tell you more about taking Januvia with a glinide drug. If you take Januvia and a glinide drug together, be sure to talk with your doctor or pharmacist. They can tell you how to manage low blood sugar.

Interaction with sulfonylureas

Januvia can interact with sulfonylureas, which are used to treat type 2 diabetes.

Examples of sulfonylurea medications include:

What could happen

Taking Januvia with a sulfonylurea can raise your risk of low blood sugar. Signs and symptoms of low blood sugar include:

  • confusion
  • dizziness
  • drowsiness
  • headache
  • hunger
  • irritability
  • nervousness
  • weakness

What you can do

If you take Januvia with a sulfonylurea drug, your doctor may prescribe a dosage of the sulfonylurea that’s lower than usual. You should not take a dose of either medication that’s higher than your doctor prescribes.

Your doctor can tell you more about taking Januvia and a sulfonylurea together. If you take Januvia and a sulfonylurea together, be sure to talk with your doctor or pharmacist. They can tell you how to manage low blood sugar.

Interaction with insulin

Januvia can interact with insulin, which is used to treat type 2 diabetes.

Examples of types of insulin include:

What could happen

Taking Januvia with insulin can raise your risk of low blood sugar. Signs and symptoms of low blood sugar include:

  • confusion
  • dizziness
  • drowsiness
  • headache
  • hunger
  • irritability
  • nervousness
  • weakness

What you can do

If you take Januvia with insulin, your doctor may prescribe a dosage of insulin that’s lower than usual. You should not take a dose of either medication that’s higher than your doctor prescribes.

Your doctor can tell you more about taking Januvia and insulin together. If you take Januvia and insulin together, be sure to talk with your doctor or pharmacist. They can tell you how to manage low blood sugar.

Januvia may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other interactions possible with Januvia.

Does Januvia interact with supplements?

Before you start taking Januvia, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Januvia and herbs

Januvia currently has no reports of interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Januvia.

Januvia and vitamins

Januvia currently has no reports of interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Januvia.

Does Januvia interact with food?

Januvia currently has no reports of interacting with food or any reports of foods to avoid while taking it. If you have questions about eating certain foods during your treatment with Januvia, talk with your doctor.

Does Januvia interact with vaccines?

Januvia currently has no reports of interacting with vaccines. If you have questions about getting certain vaccines during your Januvia treatment, talk with your doctor.

Does Januvia interact with lab tests?

Januvia currently has no reports of interacting with lab tests. If you have questions about having certain lab tests during your treatment with Januvia, talk with the healthcare professional ordering the test.

Does Januvia interact with cannabis or CBD?

Januvia currently has no reports of interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Januvia.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions or other health factors may raise the risk of interactions with Januvia. Before taking Januvia, talk with your doctor about your health history. They’ll determine whether Januvia is right for you.

Health conditions or other factors that might interact with Januvia include:

Heart failure: If you have heart failure or risk factors for it, talk with your doctor before taking Januvia. Januvia could cause symptoms of heart failure or make them worse. Your doctor can tell you whether Januvia is a safe treatment option.

Some symptoms of heart failure are:

  • shortness of breath
  • being easily fatigued after walking
  • weight gain
  • edema or peripheral edema (swelling of the feet, ankles, and legs)

Kidney problems: Worsening kidney problems with Januvia have been reported. In some cases, this has led to kidney failure and dialysis. Talk with your doctor before taking Januvia if you have kidney problems. They can tell you whether Januvia is safe and how often they need to check your kidney function.

Pancreatitis: Pancreatitis has been reported in people taking Januvia. Tell your doctor if you have or have had certain conditions that may increase the risk of pancreatitis. These include:

Tell your doctor right away if you have symptoms of pancreatitis. These may include abdominal pain or vomiting. Your doctor can tell you whether it’s safe to keep taking Januvia.

Pregnancy: It’s not known whether Januvia is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Januvia.

Breastfeeding: It’s not known whether it’s safe to take Januvia while breastfeeding. The drug may pass into breast milk. And it isn’t known whether the drug may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Januvia or any of its ingredients, your doctor likely won’t prescribe Januvia. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Find answers to some frequently asked questions about Januvia and possible interactions.

Can Januvia and glipizide be taken together?

Januvia and glipizide can be taken together, but they can interact. Specifically, taking them together can increase your risk of low blood sugar. You can read more about this interaction in the “Drug interactions explained” section above.

Talk with your doctor or pharmacist to learn more about using Januvia and glipizide together.

Are there any Januvia and Ozempic interactions?

No interactions between Januvia and Ozempic have been reported. But Januvia and Ozempic both can cause low blood sugar. So taking them together may increase the risk of low blood sugar.

Learn more about taking Januvia and Ozempic together by talking with your doctor or pharmacist.

Taking certain steps can help you avoid interactions with Januvia. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

  • whether you drink alcohol or use cannabis
  • other medications you take, as well as any vitamins, supplements, and herbs (They can also help you fill out a medication list.)
  • what to do if you start taking a new drug during your Januvia treatment

It’s also important to understand Januvia’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Januvia, ask your pharmacist to print a copy for you.)

If you have difficulty reading or understanding this information, your doctor or pharmacist can help.

Taking Januvia exactly as prescribed can also help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.