Fabrazyme (agalsidase beta) is a prescription drug that’s used to treat Fabry disease. The drug is given as an intravenous (IV) infusion by a healthcare professional. You’ll typically receive a dose every 2 weeks.

Fabrazyme is used in adults and certain children to treat Fabry disease. This is a rare, genetic (inherited) condition that may be life threatening. People with this condition have a damaged gene that causes a certain type of fat to build up in the body, which can lead to damaged organs and tissues.

The active ingredient in Fabrazyme is agalsidase beta. Fabrazyme is a biologic drug and belongs to a group of drugs called enzyme replacement therapy.

This article describes the dosage of Fabrazyme, as well as its strengths and how it’s given. To learn more about Fabrazyme, see this in-depth article.

This section describes the usual dosage of Fabrazyme. Keep reading to learn more.

What is Fabrazyme’s form?

Fabrazyme is given as an IV infusion by a healthcare professional. (An IV infusion is an injection into your vein over a period of time.)

What strengths does Fabrazyme come in?

Fabrazyme comes in two strengths: 5 milligrams (mg) and 35 mg.

What are the usual dosages of Fabrazyme?

The information below describes the dosage that’s commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for Fabry disease in adults

The typical Fabrazyme dosage for adults with Fabry disease is based on body weight in kilograms (kg). For reference, 1 kg equals about 2.2 pounds (lb).

The recommended dosage of Fabrazyme is 1 mg per kg of body weight given as an IV infusion once every 2 weeks. You’ll likely receive the infusions at your doctor’s office, an infusion center, or in a hospital.

Before you receive an infusion of Fabrazyme, your doctor may give you certain pre-treatment medications to lower your risk of serious allergic reactions. These medications include:

In some cases, you may receive a different dosage of Fabrazyme called a rechallenge dosage.

This may be necessary if you:

  • develop antibodies to Fabrazyme
  • have an allergic reaction to Fabrazyme

For a rechallenge dosage, you’ll typically receive a smaller dosage of Fabrazyme, such as 0.5 mg per kg of body weight, at a slower rate of infusion. Based on how your body tolerates this rechallenge dosage, your doctor will gradually increase your dose over time until you reach the usual recommended dose of 1 mg per kg of body weight.

Your doctor may also slow your rate of infusion if you have an infusion-related reaction (side effects related to an IV infusion).

Talk with your doctor if you have questions about your dosage of Fabrazyme.

What’s the dosage of Fabrazyme for children?

Fabrazyme is used to treat Fabry disease in children ages 2 years and older.

The dosage used in children is the same as the dosage prescribed for adults. To learn more, see the “What are the usual dosages of Fabrazyme?” section above.

For more information about Fabrazyme’s dosage for children, talk with your child’s doctor or a pharmacist.

Is Fabrazyme used long term?

Yes, Fabry disease is a genetically inherited, long-term condition. You’ll need treatment throughout your life. If you and your doctor determine that Fabrazyme is safe and effective for your condition, you’ll likely receive it long term.

You may need dosage adjustments for Fabrazyme in certain cases.

They include if you:

Your doctor will monitor you closely for side effects of the medication and adjust your dosage and rate of infusion if needed.

The dosage of Fabrazyme you’re prescribed may depend on several factors. These include:

  • side effects you may experience
  • other medications you may be taking
  • body weight
  • other conditions you may have

Fabrazyme comes as a powder that’s mixed with a liquid to make a solution. It’s given as an IV infusion by a healthcare professional. You’ll receive infusions every 2 weeks at your doctor’s office, an infusion center, or in a hospital.

Your doctor will monitor you closely for side effects during your treatment. If you have a reaction while receiving Fabrazyme, they’ll slow the rate of infusion or stop the infusion. They may also lower your dose for future infusions if you have a reaction to the drug.

Before you receive Fabrazyme infusions, your doctor may give you certain pre-medications. These include:

Your doctor will discuss your treatment and how you’ll receive Fabrazyme doses. The manufacturer of Fabrazyme also provides more information about treatment on its website.

If you miss an appointment to receive a dose of Fabrazyme, call your doctor’s office as soon as possible to reschedule. Your doctor will give you the missed dose and adjust your treatment schedule if needed.

If you need help remembering your appointments, try downloading a reminder app on your phone.

Below are answers to some commonly asked questions about Fabrazyme’s dosage.

Is Fabrazyme’s dosage similar to the dosage of Galafold?

No. Although Fabrazyme and migalastat (Galafold) are both used to treat Fabry disease, their active ingredients, forms, and dosages differ.

Fabrazyme is given as an IV infusion. It’s given by a healthcare professional once every 2 weeks, typically in a doctor’s office, infusion center, or hospital. Galafold comes as an oral capsule. It’s taken once every other day.

Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Fabrazyme to start working?

Fabrazyme works to replace the enzyme that’s not working or missing in people with Fabry disease. The drug helps break down the fats that can build up with the condition and cause harm to your organs and tissues.

It may take several months of treatment to see a reduction in your symptoms. Your doctor will monitor you during treatment to check whether the drug is working effectively.

If you have other questions about what to expect from your Fabrazyme treatment, talk with your doctor.

The sections above describe the usual dosage provided by Fabrazyme’s manufacturer. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you.

Talk with your doctor if you have questions or concerns about your current dosage.

Examples of questions you may want to ask your doctor include:

  • Will I need to have my weight checked before receiving each Fabrzyme infusion?
  • How does the dosage of Fabrazyme compare with that of agalsidase alfa (Replagal)?
  • Would my Fabrazyme dosage need to be adjusted if I have kidney problems?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.