Byooviz (ranibizumab-nuna) is a prescription drug used to treat certain eye conditions. Byooviz comes as a liquid solution for injection into the eye. It’s usually given once per month.

Byooviz is used in adults to treat:

The active ingredient in Byooviz is ranibizumab-nuna. (The reason “-nuna” appears at the end of the drug’s name is to show that it’s distinct from similar drugs that may be created in the future.)

Byooviz is a biosimilar version of the biologic drug Lucentis. (Biologic drugs are made from living cells.) Biosimilars are like generic drugs. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologics.

Byooviz belongs to a group of drugs called vascular endothelial growth factor inhibitors.

This article describes the dosages of Byooviz, as well as its strength and how it’s given. To learn more about Byooviz, see this in-depth article.

This section describes the usual dosages of Byooviz. Keep reading to learn more.

What is Byooviz’s form?

Byooviz comes as a liquid solution in single-dose vials. The drug is given as an injection into the eye by an ophthalmologist.

What strength does Byooviz come in?

Byooviz comes in one strength of 0.5 milligrams (mg) in 0.05 milliliters (mL) of solution (a concentration of 10 mg/mL).

What are the usual dosages of Byooviz?

Your dosage of Byooviz depends on the condition the drug is being used to treat. The information below describes dosages that are commonly used or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for wet AMD

The typical starting dosage of Byooviz for adults with wet AMD is one 0.5-mg/0.05-mL injection. This is given into the affected eye once per month (about every 28 days).

Once you’ve received three or four monthly injections, your doctor may give you doses of Byooviz less often.

Alternate dosing schedules include:

  • one 0.5-mg/0.05-mL injection per month for 3 months, followed by less frequent injections based on your eye exam results
  • one 0.5-mg/0.05-mL injection per month for 4 months, followed by one injection every 3 months

Note that the manufacturer of Byooviz states that receiving doses less often than once per month makes the treatment less effective. Your eye specialist will regularly check your eyes and discuss the best treatment schedule for you.

Dosage for macular edema following retinal vein occlusion

For adults with macular edema following retinal vein occlusion, the typical dosage of Byooviz is one 0.5-mg/0.05- mL injection into the affected eye once monthly (about every 28 days). Your eye specialist will discuss your dosing schedule with you.

Dosage for myopic choroidal neovascularization

The starting dosage of Byooviz for adults with myopic choroidal neovascularization is one 0.5-mg/0.05-mL injection into the affected eye once monthly (about every 28 days) for up to 3 months. After this, your eye specialist will check your eyes and may repeat Byooviz treatment if your vision has worsened or not improved.

They’ll determine your dosing schedule based on the severity of your eye condition and your response to Byooviz.

Is Byooviz used long term?

It depends. Byooviz is usually a long-term treatment for wet AMD and for macular edema following retinal vein occlusion. It’s typically used for up to 3 months for myopic choroidal neovascularization.

Your eye specialist will discuss how long you’ll receive treatment with Byooviz based on your condition and other factors such as how you respond to the medication.

The dosage of Byooviz you’re prescribed may depend on the type and severity of the condition the drug is being used to treat.

Byooviz comes as a liquid solution in single-dose vials. It’s given as an injection into the eye by an eye specialist at their office or a clinic. You’ll need someone to drive you to and from the appointment.

You’ll receive Byooviz directly into the vitreous (the jelly-like substance inside your eye) using a very fine needle. You typically won’t see or feel the needle.

Your eye doctor will check your eye pressure before and after you receive a dose of Byooviz. Be sure to call them right away if you experience any problems or side effects after receiving an injection.

If you miss an appointment to receive a dose of Byooviz, call your eye doctor’s office as soon as possible to reschedule. They’ll give you the missed dose and adjust your dosing schedule if needed.

If you need help remembering your appointments, try downloading a reminder app on your phone.

Below are answers to some commonly asked questions about the dosage of Byooviz.

Is Byooviz’s dosage similar to that of Eylea or Lucentis?

Ranibizumab (Byooviz), aflibercept (Eylea), and ranibizumab (Lucentis) are all used to treat types of eye conditions. All three drugs come as a liquid solution for injection into the eye by an ophthalmologist. How often you receive doses of these medications depends on the condition the drug is being used to treat.

Byooviz is a biosimilar version of the biologic drug Lucentis. Biosimilars are like generic drugs (which are made for nonbiologic drugs) and may cost less than brand-name biologic versions. Eylea is also a biologic drug, but it doesn’t have a biosimilar version.

The dose in milligrams for each drug differs. Your eye doctor will prescribe the drug and the dosage that’s right for you. Talk with them to learn more about how these drugs compare.

How long does it take for Byooviz to start working?

Byooviz starts to work after your first dose, but it may take several months before you notice any improvement in your vision. Because of how the drug works, you likely won’t feel it working in your body. Your eye doctor will monitor you during treatment to check whether the drug is effectively treating your condition.

If you have other questions about what to expect from your Byooviz treatment, talk with your ophthalmologist.

The sections above describe the usual dosages provided by the manufacturer of Byooviz. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you. Talk with them if you have questions or concerns about your current dosage. Examples of questions you may want to ask include:

  • Will receiving doses of Byooviz less often lower my risk of side effects?
  • How does the dosage of Byooviz compare with that of ranibizumab-eqrn (Cimerli)?
  • Will I need to stop Byooviz treatment if my eye pressure increases?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.