Augtyro (repotrectinib) is a prescription oral capsule used to treat certain types of non-small cell lung cancer in adults. Augtyro can interact with other drugs and some supplements, including birth control pills and St. John’s wort.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Before you start taking Augtyro, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Augtyro interacts with herbs or vitamins or supplements, see the “Are there other interactions with Augtyro?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Augtyro. Keep in mind that this table does not include all drugs that may interact with Augtyro. For more information about some of these interactions, see the “Drug interactions explained” section below.
| Drug group or drug name | Drug examples | What can happen |
|---|---|---|
| certain antifungals | • fluconazole (Diflucan) • itraconazole (Sporanox, Tolsura) • ketoconazole | can increase the risk of side effects from Augtyro |
| certain antibiotics | • ciprofloxacin (Cipro) • clarithromycin • erythromycin (Erytab, others) | can increase the risk of side effects from Augtyro |
| certain HIV drugs | • cobicistat (Tybost) • nelfinavir (Viracept) • ritonavir (Norvir) | can increase the risk of side effects from Augtyro |
| hormonal birth control | • ethinyl estradiol/desogestrel (Cyclessa, others) • ethinyl estradiol/drospirenone (Yaz, others) • etonogestrel (Nexplanon) | can make hormonal birth control less effective |
| certain antiarrhythmics | • amiodarone (Pacerone) • dronedarone (Multaq) • quinidine | can increase the risk of side effects from Augtyro |
| certain calcium channel blockers | • diltiazem (Cardizem CD, others) • verapamil (Verelan) | can increase the risk of side effects from Augtyro |
| certain seizure medications | • carbamazepine (Tegretol, others) • cenobamate (Xcopri) • phenytoin (Dilantin) | can make Augtyro less effective |
| midazolam (Nayzilam, Seizalam) | — | can make midazolam less effective |
| rifampin (Rifadin, Rimactane) | — | can make Augtyro less effective |
Augtyro is not known to interact with alcohol. But your doctor may recommend avoiding or limiting alcohol during your Augtyro treatment. This is because Augtyro and alcohol can cause some similar side effects, such as dizziness, balance problems, and sleepiness. So you may be more likely to experience these side effects if you drink alcohol while taking Augtyro.
If you have questions about consuming alcohol during your Augtyro treatment, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Augtyro.
Interaction with certain antibiotics
Augtyro can interact with certain antibiotics, which are used to treat bacterial infections.
Examples of antibiotics that can interact with Augtyro include:
- ciprofloxacin (Cipro)
- clarithromycin
- erythromycin (Erytab, others)
What could happen
Some antibiotics, such as those listed above, can reduce the action of certain enzymes that help remove Augtyro from your body. Taking one of these antibiotics with Augtyro can make Augtyro build up in your body. This can raise your risk of side effects from Augtyro, such as dizziness and numbness or tingling feelings.
What you can do
If you have a bacterial infection while you’re taking Augtyro, your doctor will typically avoid prescribing antibiotics that interact with Augtyro. Instead, they’ll likely prescribe an antibiotic that doesn’t interact with it.
If you have questions about taking Augtyro with antibiotics, talk with your doctor or pharmacist.
Interaction with certain seizure medications
Augtyro can interact with certain seizure medications, which are used to treat seizure disorders such as epilepsy. Some are also used for bipolar disorder and certain types of nerve pain.
Examples of seizure medications that can interact with Augtyro include:
What could happen
Some seizure medications, such as those listed above, can increase the action of certain enzymes that help clear Augtyro from your body. Taking Augtyro with one of these seizure medications can lower the amount of Augtyro in your body, which can make it less effective.
What you can do
Your doctor will typically avoid prescribing Augtyro with a seizure drug that interacts with it. If you take one of these medications, your doctor may have you switch to a different seizure medication before you start taking Augtyro. If this isn’t possible, your doctor may recommend a treatment other than Augtyro for your lung cancer.
Interaction with hormonal birth control
Augtyro can interact with birth control that contains estrogen or progesterone hormones.
Examples of hormonal birth control include:
- combination birth control pills, such as ethinyl estradiol/desogestrel (Cyclessa, others) and ethinyl estradiol/drospirenone (Yaz, others)
- progesterone-only pills (minipills), such as norethindrone (Camilla, others)
- implants, such as etonogestrel (Nexplanon)
- patches, such as ethinyl estradiol/levonorgestrel (Twirla, others)
- vaginal rings, such as ethinyl estradiol/etonogestrel (Nuvaring, others)
What could happen
Taking Augtyro with the hormonal birth control types listed above can make the birth control less effective at preventing pregnancy.
It’s important to note that if you become pregnant while taking Augtyro, the drug could cause harm to a fetus.
What you can do
If you’re able to become pregnant, you should use a nonhormonal form of birth control while taking Augtyro. Examples include condoms and diaphragms. You should continue using this for 2 months after your last dose of Augtyro. Talk with your doctor about which forms of birth control may be right for you.
If you’re male and you have a sexual partner who can become pregnant, you should use condoms during your Augtyro treatment and for 4 months after your last dose.
If you have questions about taking Augtyro with birth control, talk with your doctor.
Note: In this article, we use the term “male” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.
Augtyro may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Augtyro.
Does Augtyro interact with supplements?
Before you start taking Augtyro, talk with your doctor and pharmacist about any herbs or vitamins or supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Augtyro interactions with herbs
Augtyro can interact with St. John’s wort, an herbal supplement used to ease symptoms of depression and other conditions.
St. John’s wort can increase the action of certain enzymes that help remove Augtyro from your body. Taking St. John’s wort with Augtyro can lower the level of Augtyro in your body. This can make Augtyro less effective.
Your doctor will likely recommend that you don’t take St. John’s wort with Augtyro. You can ask them about alternatives.
There are currently no reports of Augtyro interacting with other herbs. But this doesn’t mean that interactions with other herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Augtyro.
Augtyro and vitamins
There are currently no reports of Augtyro interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Augtyro.
Does Augtyro interact with food?
Augtyro can interact with grapefruit and grapefruit juice. Your doctor will likely recommend that you avoid consuming grapefruit while taking Augtyro.
Grapefruit can reduce the action of certain enzymes that help remove Augtyro from your body. Consuming grapefruit while taking Augtyro can cause the drug to build up in your body. This can raise your risk of side effects from Augtyro, such as dizziness and numbness or tingling feelings.
If you have questions about consuming other foods or drinks while taking Augtyro, talk with your doctor or pharmacist.
Does Augtyro interact with vaccines?
There are currently no reports of Augtyro interacting with vaccines. If you have questions about getting certain vaccines during your Augtyro treatment, talk with your doctor.
Does Augtyro interact with lab tests?
There are currently no reports of Augtyro interacting with lab tests. If you have questions about having certain lab tests done during your treatment with Augtyro, talk with the healthcare professional ordering the test.
Does Augtyro interact with cannabis or CBD?There are currently no reports of Augtyro interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Augtyro.
Keep in mind that cannabis and Augtyro can cause some similar side effects, such as sleepiness and problems with memory, thinking, or concentrating. So you may be more likely to have these side effects if you use cannabis with Augtyro.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Augtyro. Before taking Augtyro, talk with your doctor about your health history. They’ll determine whether Augtyro is right for you.
Health conditions or other factors that might interact with Augtyro include:
Liver problems: If you have a liver problem, Augtyro could make it worse. Your doctor will monitor your liver function during your Augtyro treatment.
Neurological problems: If you have a neurological (nervous system) problem, Augtyro could make your symptoms worse. Talk with your doctor about whether this drug is right for you.
Gout: Augtyro can increase your uric acid levels. With gout, you have a buildup of uric acid. If you have this condition, taking Augtyro may worsen it. Your doctor will monitor your uric acid levels while you’re taking Augtyro and may adjust your gout treatment if needed.
Pregnancy: Augtyro is not safe to take during pregnancy. The drug can cause harm to a fetus. If you’re pregnant or planning a pregnancy, talk with your doctor about your treatment options.
Birth control: Augtyro can make hormonal birth control less effective. For more details, see the “Drug interactions explained” section above.
If you’re able to become pregnant, you should use a nonhormonal form of birth control, such as condoms, while taking Augtyro. You should continue using this for 2 months after your last dose of Augtyro. Talk with your doctor about which type of birth control may be right for you.
If you’re male and have a sexual partner who can become pregnant, you should use condoms during your Augtyro treatment and for 4 months after your last dose.
Breastfeeding: It’s not known whether Augtyro passes into breast milk. However, if it does, it could cause serious side effects in a child who’s breastfed. Your doctor will likely recommend that you do not breastfeed while taking Augtyro and for 10 days after your last dose. If you’re breastfeeding or planning to do so, talk with your doctor about your options.
Allergic reaction: If you’ve had an allergic reaction to Augtyro or any of its ingredients, your doctor will likely not prescribe Augtyro. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Taking certain steps can help you avoid interactions with Augtyro. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- whether you drink alcohol or use cannabis
- other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a
medication list ) - what to do if you start taking a new drug during your Augtyro treatment
It’s also important to understand Augtyro’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Augtyro exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.